What is the Endocannabinoid System?
The Endocannabinoid System is the reason why Cannabis works on the human body and why it has so many medicinal qualities. Endocannabinoids (internally produced cannabinoids, e.g. Anandamide) interact with cannabinoid receptors (e.g. CB1, CB2), which are present throughout our body. We have this system to “relax, eat, sleep, protect, and forget”, as was summarized by one of the world’s leading cannabinoid scientists Vincenzo Di Marzo, PhD in 1998. Since then many other roles have been additionally discovered, including pain control, feeling euphoria (e.g. “runner’s high”), and homeostasis (the inner balance). Phytocannabinoids (plant cannabinoids, e.g. THC, CBD) give our system a boost by interacting with our receptors.
Cannabis helps to restore normal function of the cells and systems, and most importantly, it helps to maintain the inner balance of the human body and mind (Homeostasis). Homeostatic function is the cornerstone of the Endocannabinoid System and the main reason why so many patients successfully control numerous symptoms and conditions with Medical Cannabis and get to eliminate or significantly reduce the burden of synthetic pharmaceutical drugs, their associated costs and adverse effects.
A Note from the Doctor:
“The variety of medical applications of Cannabis are remarkable. A relatively recent (early 1990s) discovery of the Endocannabinoid System (internally produced cannabinoids and their receptors) found to be present in nearly every living organism – is one of the greatest breakthroughs in Physiology and Medicine. This helped us understand how one plant could safely and effectively treat a myriad of medical conditions since ancient times. The knowledge in this field is rapidly expanding with over 30,000 studies already published and multiple new studies coming out every day. I am excited that medical schools are starting to include this important subject into educational programs. At present, each practicing physician is required to have an extensive education before applying Cannabis and its numerous constituents to the treatment of patients. I am eager and enthusiastic to share my acquired knowledge with patients in order to help them relieve debilitating symptoms and heal with the help of this extraordinary medicinal plant.”— Alex Bibikau, M.D.
Evolution of the knowledge on Cannabis, Cannabinoids, and the Endocannabinoid System:
PubMed Database search:
- 1961 – 1991 “endocannabinoid” 5 results.
- 1992 – 2022 “endocannabinoid” 12,304 results.
- 1961 – 1991 “cannabinoid” 1,812 results.
- 1992 – 2022 “cannabinoid” 29,564 results.
- 1961 – 1991 “cannabis” 4,645 results.
- 1992 – 2022 “cannabis” 25,481 results.
History of Cannabis and the Endocannabinoid system
The Endocannabinoid System and its Modulation by Phytocannabinoids